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KMID : 0616120110420010032
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Korean Journal of Pharmacognosy
2011 Volume.42 No. 1 p.32 ~ p.37
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Ameliorating Effects of Herbal Ethanol Extract from Gynostemma pentaphyllum on Chronic Stress-Induced Anxiety in Mice
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Choi Hyun-Sook
Shin Kun-Seong
Choi Soon-Ok
Kim Seung-Hwan
Hwang Bang-Yeon
Lee Chong-Kil
Lee Myung-Koo
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Abstract
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The effects of herbal ethanol extract from Gynostemma pentaphyllum (GP extract) on chronic stress-induced anxiety in mice were investigated. The animals were treated with GP extracts (50 and 100 mg/kg/day, p.o.) for 21 days before exposure to electric footshock (EF; duration and interval 10 sec for 3 min, 2 mA) for chronic stress once a day. The ambulatory locomotor activity was reduced by chronic EF stress and it was recovered by 12.9-15.1% in GP extract-treated groups. The grip strength was also significantly decreased by chronic EF stress, however, the EF-stressed groups treated with GP extract increased grip strength from 13.9% to 56.8% compared to EF-stressed groups. In addition, the serum levels of corticosterone were significantly elevated by chronic EF stress to 197% of the control levels, which was reduced to 73.1% by treatment with GP extract (100 mg/kg). In contrast, the brain levels of dopamine and serotonin were reduced to 67.6% and 63.1% by chronic EF stress, which was recovered to 90% of the control levels by treatment with GP extract. These results indicate that GP extract shows the ameliorating effects on chronic EF stress-induced anxiety in mice and it can be developed as the promising anti-anxiety agent.
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KEYWORD
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Gynostemma pentaphyllum, Chronic stress-induced anxiety, Ambulatory locomotor activity, Grip strength, Corticosterone, Dopamine, Serotonin
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